Artificial insemination by frozen donor semen: results of multicentre Australian experience

Abstract

A total of 5461 insemination cycles with frozen donor semen were analyzed for 8 of the larger AID [artificial insemination of donor semen] services in Australia. Cumulative pregnancy rate, calculated by life-table analysis, showed that 50% of all patients are pregnant after 6 cycles of insemination and 64% of all patients are pregnant after 12 cycles of insemination. Pregnancy rate was significantly higher in the first 3 cycles, declined in the next 3 cycles and was further reduced in the last 6 cycles of insemination. An average of 10% of all insemination cycles were anovular, but the proportion of anovular cycles was significantly lower in the first 2 cycles of insemination. There was no significant difference in cumulative pregnancy rates over the first 6 cycles of insemination in clinics using cervical mucus scoring or luteinizing hormone assay for detection of ovulation. An average of 12% of all pregnancies obtained by AID resulted in miscarriage.