Inhibition of Mouse Encephalomyelitis Virus, in vitro, by Certain Nucleoprotein Derivatives.

Abstract

Adenine, adenosine, cytidine, guanosine and thymine inhibit the propagation of Theiler''s GDVII strain of murine encephalomyelitis virus in tissue cultures of 1-day mouse brain. Guanine, uridine, uracil, guanylic or cytidylic acids did not inhibit. Various substituted nucleosides including amino-, chloro-, diazo-, formamido-, hydroxy- and methyluridine were inhibitory. Uridine partially reversed this inhibition. 5-Chlorouracil, ribosylthymine and glucosylthymine did not inhibit; 2,6-diaminopurine did. 5-Chlorouridine was not effective against this viral infection in mice.