Intestinal Absorption of Vitamin B12in Patients with Chronic Pancreatic Insufficiency and the Effect of Human duodenal Juice on the Intestinal Uptake of Vitamin B12
- 1 November 1976
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 11 (7), 689-695
- https://doi.org/10.1080/00365521.1976.12097174
Abstract
The mean absorption of vitamin B12 (Schilling test) was 13.1 +/- 1.0 (% +/- S.E.M.) in 21 patients with chronic pancreatic insufficiency and 17.6 +/- 1.4 in 13 control patients (p less than 0.01). There was no correlation between pancreatic bicarbonate production after secretion stimulation and vitamin B12 absorption in the patient group (r = 0.117). Human duodenal juice reduced the uptake of 57CoB12-rat intrinsic factor (IF) by perfused rat small intestinal segments in vivo (p less than 0.01) as well as the uptake of 57CoB12-human IF by purified guinea-pig intestinal brush borders in vitro (p less than 0.01). The results confirm reduced absorption of vitamin B12 in chronic pancreatic insufficiency, but the mechanism remains uncertain.Keywords
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