Immune functions encoded by the natural killer gene complex
Top Cited Papers
- 1 April 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (4), 304-316
- https://doi.org/10.1038/nri1055
Abstract
There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.Keywords
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