The effect of iron on the biodistribution of bone scanning agents in humans.

Abstract

Patients (9) with chronic Fe overload, resulting from repeated transfusions or hemochromatosis, had bone scans that were characterized by a reduction of bony uptake, increased renal activity and a significant increase in soft-tissue accumulation of 99mTc-labeled bone-seeking agents. Findings were supported by semiquantitative computer analysis. The probable mechanisms of altered biodistribution and the possible role of serum ferritin are discussed. The importance of realizing the effect of excess Fe on skeletal scintigraphy is further emphasized by the results of bone scanning in another patient in whom acute Fe overload following infusion of Fe-dextran resulted in excessive blood pool labeling.