Metabolism in Diabetic Coma Produced by Alloxan
- 2 November 1945
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 102 (2653), 447-449
- https://doi.org/10.1126/science.102.2653.447
Abstract
Alloxan injected intraperit. into fasting rats in a single dose of 200 mg./kg. caused a state of diabetic coma analogous to severe human coma. In these animals plasma inorganic P and blood sugar rose, liver glycogen and total acid-soluble P decreased. An increase in liver inorganic P occurred with a concurrent fall in adenosine pyrophosphate and other organophosphates. Very large doses of insulin caused improvement in both the clinical and chemical states of comatose rats.This publication has 6 references indexed in Scilit:
- THE EFFECT OF ADRENALECTOMY ON ALLOXAN DIABETESEndocrinology, 1945
- STUDIES WITH RADIOACTIVE PHOSPHORUS OF THE CHANGES IN THE ACID-SOLUBLE PHOSPHATES IN THE LIVER COINCIDENT TO ALTERATIONS IN CARBOHYDRATE METABOLISMPublished by Elsevier ,1944
- THE ACTION OF INSULIN ON THE PHOSPHATE CYCLEPublished by Elsevier ,1944
- RADIOACTIVE PHOSPHATE AS AN INDICATOR OF THE RELATIONSHIP BETWEEN THE PHOSPHATE CHANGES OF BLOOD, MUSCLE AND LIVER, FOLLOWING THE ADMINISTRATION OF INSULINAmerican Journal of Physiology-Legacy Content, 1944
- THE INFLUENCE OF FASTING, EPINEPHRINE, AND INSULIN ON THE DISTRIBUTION OF ACID-SOLUBLE PHOSPHORUS IN THE LIVER OF RATSPublished by Elsevier ,1942
- ROLE OF ACID-SOLUBLE PHOSPHORUS COMPOUNDS IN RED BLOOD CELLSAmerican Journal of Diseases of Children, 1939