RADIOACTIVE PHOSPHATE AS AN INDICATOR OF THE RELATIONSHIP BETWEEN THE PHOSPHATE CHANGES OF BLOOD, MUSCLE AND LIVER, FOLLOWING THE ADMINISTRATION OF INSULIN

Abstract

The different concepts that have been advanced to explain the phosphate changes in blood and tissues following the adm. of insulin have been tested by tracer expts. with radio-active inorganic phosphate. This brings to light relationships which are difficult to detect by ordinary chemical analysis. The results indicate that insulin facilitates the transfer of inorganic phosphate from blood to tissues, in particular the liver, and promotes the phosphorylation of glucose. The mechanism of insulin action is probably the same in blood, muscle and liver.