A Comparison of Leukocyte Alkaline Phosphatase Determinations in 200 Patients with Mongolism and in 200 Familial Controls
- 23 May 1963
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 268 (21), 1168-1170
- https://doi.org/10.1056/nejm196305232682106
Abstract
SINCE 1939, when Gomori1 first demonstrated alkaline phosphatase activity in the cells of the blood and bone marrow, interest has been centered on the significance of this enzyme in the cells and on the variations in its concentration in different clinical entities. The alkaline phosphatase activity of the polymorphonuclear leukocytes is diminished in chronic myelogenous leukemia.2 3 4 At the same time evidence has been accumulating that an abnormally small acrocentric chromosome (No. 21, Denver classification) is present in most cases of chronic myelogenous leukemia5; this has been called the Philadelphia chromosome, or more correctly Ph.Patients with mongolism have been . . .This publication has 15 references indexed in Scilit:
- ALKALINE-PHOSPHATASE ACTIVITY OF POLYMORPHS IN MONGOLISMThe Lancet, 1962
- GENES ON THE MONGOL CHROMOSOME?The Lancet, 1962
- THE LEUCOCYTE ALKALINE PHOSPHATASE IN MONGOLISMThe Lancet, 1962
- EVOLUTION AND DIFFERENTIATION OF DEHYDROGENASES*Annals of the New York Academy of Sciences, 1961
- CYTOGENETIC STUDIES IN CHRONIC MYELOID LEUKÆMIA AND ACUTE LEUKAÆMIA ASSOCIATED WITH MONGOLISMThe Lancet, 1961
- Diseases or Clinical Conditions Associated with Low Leukocyte Alkaline PhosphataseNew England Journal of Medicine, 1960
- Gamma Globulin against Rubella in Pregnancy II. Manijest Maternal Rubella in Early Pregnancy Treated with Convalescent Gamma Globulin: a Follow‐Up StudyActa Paediatrica, 1959
- THE SOMATIC CHROMOSOMES IN MONGOLISMThe Lancet, 1959
- A Survey of Childhood MalignanciesBMJ, 1958
- Microtechnical Demonstration of Phosphatase in Tissue Sections.Experimental Biology and Medicine, 1939