Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction

Abstract

The effects of physical training on hemostatic parameters were evaluated in 56 postmyocardial infarction (MI) patients before and after one month of systematic physical training and in 30 control post‐MI patients, who did not undergo such training. There were no significant changes in prothrombin time (PT) and alpha₁‐ antitrypsin (α₁AT) at the beginning and end of the study in either group. Levels of fibrinogen, Factor VIII: C (VIILC) and von Wildebrand antigen (vWf:Ag), and activities of ATIII and plasminogen (Plg) were significantly decreased in the group with physical training (p2‐plasmin inhibitor (α₂PI) activities also decreased in the physical training group (p< 0.05). In contrast, these variables increased in the control group (p 2PI complex (PIC), thrombin‐antithrombin III complex (TAT), protein‐C (P‐C:Ag), plasminogen activator inhibitor‐1 (PAI‐1), VII:C, and P‐C activities had significantly decreased after one month of physical training (p2PI, PAI‐1, and PIC after physical training may result from the decreased coagulability. In conclusion, physical training appears to induce a suppression of the coagulation system in patients in the recovery phase of MI.