Serum Antidiuretic Substances and Urinary Corticosteroid in The Human*

Abstract
Measure-ments of serum antidiuretic substances (ADS) by the method of Birnie et al. and of urinary corticosteroid by a method permitting analysis of poorly water-soluble steroids were made in normal humans and in patients with Addison''s disease, diabetes insipidus, Laennec''s cirrhosis and premenstrual water retention. In all subjects studied, water retention was associated with relatively high ADS and low corticosteroid. Diuresis was associated with relatively low ADS and high corticosteroid.