SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist
- 23 July 1996
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 6 (14), 1623-1628
- https://doi.org/10.1016/0960-894x(96)00287-9
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell LineJournal of Neurochemistry, 1994
- Synthesis of RPR 100893, prototype of a new series of potent and selective non peptide NK1 antagonists : the triarylperhydroisoindolols.Bioorganic & Medicinal Chemistry Letters, 1994
- The tachykinin NK1 receptor antagonist CP-99,994 attenuates cisplatin induced emesis in the ferretEuropean Journal of Pharmacology, 1993
- Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the ratBritish Journal of Pharmacology, 1993
- Neurotransmitter functions of mammalian tachykinins.Physiological Reviews, 1993
- Tachykinin receptors and tachykinin receptor antagonistsJournal of Autonomic Pharmacology, 1993
- Discovery of a potent substance P antagonist: recognition of the key molecular determinantJournal of Medicinal Chemistry, 1992
- A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) ReceptorScience, 1991
- Modulation of neurogenic inflammation: novel approaches to inflammatory diseaseTrends in Pharmacological Sciences, 1990
- Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of ArthritisScience, 1987