Limulus amebocyte lysate reaction with streptococcal pyrogenic exotoxin

Abstract
Three immunologically distinct pyrogenic exotoxins derived from group A streptococci [Streptococcus pyogenes] cause coagulation of Limulus amoebocyte lysate. These exotoxins were several thousand times less active for lysate coagulation than [Salmonella typhosa] gram-negative endotoxin.