THE THYROID GLAND AND THE SENSITIVITY OF ANIMALS TO INSULIN
- 1 February 1928
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 84 (1), 132-140
- https://doi.org/10.1152/ajplegacy.1928.84.1.132
Abstract
An increase in sensitivity to insulin is observed for 10-20 days after complete thyroidectomy (with preservation of parathyroids); approximately of the pre-operative reactive dose is sufficient to produce hypoglycemic symptoms during this period. Complete recovery of the normal resistance to insulin occurs in 20-30 days, and 35-40 days after thyroid removal a heightened tolerance is observed. Ablation of the adrenal medulla now produced an extreme and permanent hypersensitivity to minute doses of insulin. Typical adrenalin hyperglycemia could be induced, and adrenalin or pituitrin abolished convulsions, in thyroidectomized cats. The liver and muscle contained normal amounts of glycogen.This publication has 2 references indexed in Scilit:
- Die Wirkung der Pankreasexstirpation und der darauf folgenden Thyreoektomie auf die Empfindlichkeit von Hunden gegen InsulinPflügers Archiv - European Journal of Physiology, 1927
- ON THE ALLEGED ANTAGONISTIC ACTION OF THE INTERNAL SECRETIONS OF THE PANCREAS AND THE THYROIDAmerican Journal of Physiology-Legacy Content, 1927