Effect of Certain Androgenic Steroids and Cortisone on Gastric Ulcerogenesis in Fasting Rats
- 1 May 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (1), 147-150
- https://doi.org/10.3181/00379727-101-24862
Abstract
The effect of 17-ethyl-19-nor-testosterone (E.N.T.) and testosterone enanthate (T.E.) on development of gastric ulcers in fasting cortisone treated rats was studied. Pretreatment of rats with E.N.T. gave a very marked protection against ulcers in cortisone treated rats. It was also noted that S35 uptake by sulphated mucopolysaccharides of gastric tissue was significantly reduced in cortisone treated fasting rats as compared with rats fasting only, or those given E.N.T. prior to cortisone. Androgen T.E. had no marked protective action. No direct parallelism was noted between surviving rate and ulcer occurrence in steroid treated fasting rats.Keywords
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