OBSERVATIONS ON THE UPTAKE OF RADIOSULPHATE BY THE GASTRIC TISSUE AND GASTRIC SECRETION IN HISTAMINE-TREATED GUINEA PIGS
- 1 August 1958
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 36 (8), 847-853
- https://doi.org/10.1139/o58-091
Abstract
The effect of histamine on the uptake of radiosulphate by gastric tissue and gastric juice in guinea pigs was investigated. Radioactivity was recorded 4 hours after the administration of S35-labelled sulphate to normal controls and to histamine-treated animals. The radioactivity of fractions considered to contain sulphated mucopolysaccharides was also investigated. The uptake of radiosulphate by gastric tissue and juice was significantly higher in histamine-treated animals than in control guinea pigs. The S35 uptake by gastric sulphomucopolysaccharides was considered to represent the concentration of isotope by mucous cells and its secretion. This selective uptake was also markedly effected by histamine. Histamine may be a stimulant of the gastric mucous cells under the experimental conditions described.Keywords
This publication has 9 references indexed in Scilit:
- The deposition of 35S in cortical boneBiochemical Journal, 1956
- THE UPTAKE OF RADIOSULFUR IN THE FRACTURED HUMERUS IN THE RAT1956
- The distribution of the sulphated mucopolysaccharides in the mouseThe Journal of Pathology and Bacteriology, 1955
- The Relationship of the Basophil to Blood Histamine in ManBlood, 1955
- Autoradiographic visualization of S35 incorporation and turnover by the Mucous Glands of the gastro‐intestinal tract and other soft tissues of rat and hamsterThe Anatomical Record, 1954
- EFFECT OF AGE ON SOME ASPECTS OF SULFATE METABOLISM IN THE RATThe Journal of Experimental Medicine, 1954
- ISOLATION OF CHONDROITIN SULFATES-S35 FROM ARTICULAR CARTILAGE OF RATSJournal of Biological Chemistry, 1951
- RATE OF EXCRETION OF RADIOACTIVE SULFUR AND ITS CONCENTRATION IN SOME TISSUES OF THE RAT AFTER INTRAPERITONEAL ADMINISTRATION OF LABELED SODIUM SULFATEJournal of Biological Chemistry, 1949
- THE EFFECT OF PILOCARPINE ON MUCUS SECRETION BY THE PYLORIC MUCOSA1946