Effects of Intravenous Lidocaine on Isoflurane Concentration, Physiological Parameters, Metabolic Parameters and Stress‐related Hormones in Horses Undergoing Surgery
- 19 May 2003
- journal article
- Published by Wiley in Journal of Veterinary Medicine Series A
- Vol. 50 (4), 190-195
- https://doi.org/10.1046/j.1439-0442.2003.00523.x
Abstract
Physiological parameters, metabolic parameters and stress-related hormones are evaluated in horses anaesthetized with isoflurane in oxygen combined with lidocaine intravenously. Two groups of horses anaesthetized with isoflurane (six horses in each group) were studied: a lidocaine group (IL), which received intravenous lidocaine and a control group (C), which received intravenous saline. Horses in both groups were premedicated with detomidine (i.v.), and anaesthesia was induced with midazolam-ketamine (i.v.). The lidocaine group received intravenous lidocaine as a loading dose of 2.5 mg kg(-1) at 15 min after induction of anaesthesia directly followed by a maintenance dosage of 50 microg kg(-1) min(-1), while the control group received saline (i.v.) following the same regime. End-tidal isoflurane and standard physiological parameters were measured. Blood was sampled for measurement of lidocaine, stress hormones and metabolic parameters. The end-tidal isoflurane concentration in the lidocaine group was 0.96 +/- 0.06% versus 1.28 +/- 0.06% (mean +/- SD) in the control group, a significant (P < 0.05) reduction of 25%. No significant differences were found regarding stress-related hormones, metabolic and physiological parameters. This study suggests that the use of lidocaine to decrease the concentration of isoflurane to obtain a sufficient surgical anaesthesia has no subsequent effects on physiological and metabolic parameters or stress-related hormones.Keywords
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