Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions
- 16 November 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4113), 717-720
- https://doi.org/10.1126/science.182.4113.717
Abstract
Rats given intraventricular injections of 6-hydroxydopamine after pretreatment with pargyline become aphagic and adipsic, and show severe loss of brain catecholamines. Like rats with lateral hypothalamic lesions, these animals gradually recover ingestive behaviors, although catecholamine depletions are permanent. Both groups decrease food and water intakes markedly after the administration of α-methyltyrosine, at doses that do not affect the ingestive behaviors of control rats. Thus, both the loss and recovery of feeding and drinking behaviors may involve central catecholamine-containing neurons.Keywords
This publication has 33 references indexed in Scilit:
- LH syndrome and brain catecholamine levels after lesions of the nigrostriatal bundlePhysiology & Behavior, 1972
- Norepinephrine: Reversal of Anorexia in Rats with Lateral Hypothalamic DamageScience, 1971
- EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAINJournal of Neurochemistry, 1970
- Relationship of body weight to the lateral hypothalamic feeding syndrome.Journal of Comparative and Physiological Psychology, 1970
- The effect of diencephalic lesions on food intake and motor activityPhysiology & Behavior, 1969
- Localization of the Adrenergic Feeding System in the Rat DiencephalonScience, 1967
- Aphagia and adipsia following unilateral and bilaterally asymmetrical lesions in ratsPhysiology & Behavior, 1967
- Differential effects of amphetamine on food and water intake in rats with lateral hypothalamic lesions.Journal of Comparative and Physiological Psychology, 1964
- Medial forebrain bundle and “feeding centers” of the hypothalamusJournal of Comparative Neurology, 1961
- Recovery from the Failure to Eat Produced by Hypothalamic LesionsScience, 1954