Effects of Hormone Administration on Serum Protein Patterns.

Abstract

Total serum protein concentration increased on cortisone administration; no other hormone tested had a significant effect. Pituitary adrenocorti-cotropic hormone decreased the serum albumin concentration. Testosterone, hydrocortone and cortisone increased the serum albumin concentration. Insulin increased the concentration of alpha1 globulins. Estrogen produced an increase in the alpha2 globulin concentration, which appeared as a double band. Hydrocortone, but not cortisone, depressed the serum gamma globulin concentration. The other pituitary and adrenal hormones, progesterone and thyroxine, were without effect on the serum protein pattern.