Diminution of insulin effect by growth hormone in hypophysectomized dogs; studies with C14 glucose
- 31 January 1959
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 196 (2), 231-234
- https://doi.org/10.1152/ajplegacy.1959.196.2.231
Abstract
The mechanism whereby growth hormone diminishes the hypoglycemic effect of insulin was investigated in hypophysectomized dogs using a C14 glucose dilution technique. An intravenous injection of insulin into the normal dog increased the rate of glucose utilization, and the resulting hypoglycemia was promptly abolished by an increased rate of glucose production. In the hypophysectomized dog prior to growth hormone administration, the insulin injection increased the rate of glucose utilization to a greater extent than in the normal animal, while the ability to increase the rate of glucose production was shown to be limited. In the hypophysectomized dog, a growth hormone regimen (1 mg/kg/day for 4 days) increased the rate of glucose production and utilization. The intravenous injection of insulin during the growth hormone regimen resulted in a lesser increase in the rate of plasma glucose utilization than observed prior to the growth hormone regimen. Furthermore, the growth hormone regimen improved the animal's limited ability to increase glucose production in response to the insulin-induced hypoglycemia. These effects of growth hormone contribute to the decreased effectiveness of insulin. The relationship of the ‘anti-insulin’ effect of growth hormone to its influence on glucose turnover is discussed.Keywords
This publication has 7 references indexed in Scilit:
- Increased Production and Utilization of Circulating Glucose During Growth Hormone Regimen.Experimental Biology and Medicine, 1957
- Mechanism of Insulin Hypersensitivity in the Hypophysectomized DogAmerican Journal of Physiology-Legacy Content, 1957
- Single Phototube Liquid Scintillation Counting of C14: Application to an Easily Isolated Derivative of Blood GlucoseJournal of Applied Physiology, 1957
- Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution MethodAmerican Journal of Physiology-Legacy Content, 1956
- Carbohydrate Metabolism of Hypophysectomized Dogs as Studied With Radioactive GlucoseAmerican Journal of Physiology-Legacy Content, 1956
- Current Concepts of the Action of InsulinPhysiological Reviews, 1954
- THE QUANTITATIVE RELATION BETWEEN INSULIN AND ITS BIOLOGICAL ACTIVITYJournal of Biological Chemistry, 1953