Effect of Acute Intravenous Administration of Isoproterenol on Cardiorenal Hemodynamics in Man

Abstract

By the direct Fick, or the indocyanine-green or both, methods and by renal clearance of inulin and para-aminohippurate (PAH), simultaneous cardiorenal hemodynamic observations were made before and during isoproterenol infusion (0.9-2.6 µg/ min) into three patients without, and 10 patients with, heart disease. Although a consistent increase in cardiac output (11 to 147%) was noted in all patients, no significant change in glomerular filtration rate or renal blood flow was observed. The percentage of the cardiac output delivered to the kidney during drug infusion decreased in all subjects. The renal extraction of PAH, measured in three patients, was not changed during isoproterenol administration. The infusion of isoproterenol to normovolemic and hypervolemic dogs (10 dogs) increased the cardiac output in all animals but produced no significant change in glomerular filtration rate or renal blood flow. Because the renal blood flow is not affected by the increased cardiac output produced by isoproterenol, the data suggest that there is either a weak or an absent beta-receptor response in the kidney in the dog and man.