Role of irritable bowel syndrome in subjective lactose intolerance
Open Access
- 1 April 1998
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 67 (4), 710-715
- https://doi.org/10.1093/ajcn/67.4.710
Abstract
It has been suggested that the symptoms of irritable bowel syndrome (IBS) may be wrongly attributed to lactose intolerance. We examined the relations among IBS, demographic factors, living habits, and lactose intolerance. On the basis of a lactose tolerance test with ethanol, 101 of the 427 healthy subjects studied were lactose maldigesters and 326 were lactose digesters. IBS was diagnosed by means of the Bowel Disease Questionnaire, according to the Rome criteria. The use of dairy products and symptoms experienced after their consumption were recorded. IBS was found in 15% of both the lactose maldigesters and lactose digesters. One-third of the subjects reported intolerance to dairy products containing < or = 20 g lactose. About half of this third were lactose maldigesters and about half were lactose digesters. As explanations for this subjective lactose intolerance, the logistic regression model estimated lactose maldigestion (odds ratio: 10.3; 95% CI: 5.2, 20.4), IBS (4.6; 2.1, 10.1), experience of symptoms other than gastrointestinal ones (2.3; 1.2, 4.5), and female sex (2.1; 1.1, 4.0). Characteristics common to both subjective lactose intolerance and IBS were female sex and the experience of abdominal pain in childhood (P < 0.01). Age, regularity of meals, and the amount of physical activity were not associated with either subjective lactose intolerance or IBS. Of the subjects with IBS, the percentage of lactose maldigesters was the same as in the whole study group (24%) but the number who reported lactose intolerance was higher (60% compared with 27%, P < 0.001). We showed a strong relation among subjective lactose intolerance, IBS, the experience of abdominal pain in childhood, and female sex.Keywords
This publication has 32 references indexed in Scilit:
- Lactobacillus GG Modulates Milk-Induced Immune Inflammatory Response in Milk-Hypersensitive AdultsNutrition Today, 1996
- PSYCHOSOCIAL ASPECTS OF FUNCTIONAL GASTROINTESTINAL DISORDERSGastroenterology Clinics of North America, 1996
- How Much Lactose is Low Lactose?Journal of the American Dietetic Association, 1996
- Initial validation of a bowel symptom questionnaire* and measurement of chronic gastrointestinal symptoms in AustraliansAustralian and New Zealand Journal of Medicine, 1995
- More accurate diagnosis of irritable bowel syndrome by the use of 'non-colonic' symptomatology.Gut, 1991
- Non-colonic features of irritable bowel syndrome.Gut, 1986
- Hydrogen breath test quantification and clinical correlation of lactose malabsorption in adult irritable bowel syndrome and ulcerative colitisDigestive Diseases and Sciences, 1984
- Manifestation and occurrence of selective adult-type lactose malabsorption in Finnish teenagersDigestive Diseases and Sciences, 1978
- Hypolactasia and the Irritable Colon SyndromeScandinavian Journal of Gastroenterology, 1972
- Diagnosis of Lactose Malabsorption by the Lactose Tolerance Test with Peroral Ethanol AdministrationScandinavian Journal of Gastroenterology, 1969