Immunochemical Analysis of the Cross-Reacting Idiotypes of Mouse Myeloma Proteins with Anti-Dextran Activity and Normal Anti-Dextran Antibody
- 1 January 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (1), 235-239
- https://doi.org/10.1073/pnas.70.1.235
Abstract
The idiotype of the mouse myeloma protein with anti-alpha-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with alpha1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.Keywords
This publication has 17 references indexed in Scilit:
- Genetics of the Antibody Response to Dextran in MiceScience, 1972
- Immunochemical studies on mouse myeloma proteins with specificity for dextran or for levanImmunochemistry, 1972
- Variability in the Lambda Light Chain Sequences of Mouse AntibodyNature, 1970
- QUANTITATIVE INVESTIGATIONS OF IDIOTYPIC ANTIBODIESThe Journal of Experimental Medicine, 1970
- A Genetic Marker in the Variable Region of Light Chains of Mouse ImmunoglobulinsProceedings of the National Academy of Sciences, 1970
- Solid phase radioimmunoassay of human β 1C globulinImmunochemistry, 1970
- Experimental approaches tohomogenous antibody populations. iIndividual antigenic specificity, cross specificity and diversity of human antibodies.1970
- The Use of Affinity Chromatography for the Specific Purification of Antibodies and AntigensThe Journal of Immunology, 1969
- Genetics of Immunoglobulins in the MouseAdvances in Immunology, 1967
- Heterogeneity in dextran preparationsArchives of Biochemistry and Biophysics, 1955