The Influence of Increased Tubular Hydrostatic Pressure on Renal Function
- 1 April 1976
- journal article
- review article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 115 (4), 427-432
- https://doi.org/10.1016/s0022-5347(17)59227-7
Abstract
The effect of tubular obstruction on renal function has been understood poorly at the tubular level and from the clinical standpoint. In our review the evidence for a direct influence of hydrostatic pressure on tubular transport and glomerular filtration is examined. The data generated to date indicate a direct influence of hydrostatic pressure on tubular transport only at the level of the distal convoluted tubule and collecting duct. With respect to glomerular filtration increased tubular pressure reduces the net driving force for filtration and reduces glomerular filtration rate in the absence of a compensatory increase in glomerular hydrostatic pressure. We next review physiological data concerning the mechanism of post-obstructive diuresis. Available information suggests 4 factors that play a significant role in the clinical syndrome of post-obstructive diuresis: 1) medullo-papillary washout, 2) decreased fractional and absolute salt and water reabsorption in the collecting duct, presumably secondary to direct influence of hydrostatic pressure on transport mechanisms, 3) osmotic diuresis secondary to retention of urea and other osmotic solutes during the period of obstruction and 4) prior salt and water administration in the absence of excretion, resulting in extracellular fluid volume expansion.Keywords
This publication has 11 references indexed in Scilit:
- A functional comparison of the cortical collecting tubule and the distal convoluted tubule.JCI Insight, 1975
- A Micropuncture Study of Postobstructive Diuresis in the RatJCI Insight, 1972
- Flow dependence of transtubular potential difference in isolated perfused segments of rabbit proximal convoluted tubuleJCI Insight, 1971
- Effect of vasopressin on electrical resistance of renal cortical collecting tubulesAmerican Journal of Physiology-Legacy Content, 1971
- Sodium chloride and water transport in the descending limb of HenleJCI Insight, 1970
- The nature of transtubular Na and K transport in isolated rabbit renal collecting tubulesJCI Insight, 1970
- Control of fluid absorption in the renal proximal tubuleJCI Insight, 1968
- Massive polyuria and natruresis following relief of urinary tract obstructionAmerican Journal Of Medicine, 1964
- Extreme Polyuria in Obstructive UropathyNew England Journal of Medicine, 1956
- Micropuncture Study of Pressures in Proximal Tubules and Peritubular Capillaries of the Rat Kidney and Their Relation to Ureteral and Renal Venous PressuresAmerican Journal of Physiology-Legacy Content, 1956