Isolation of morphine from toad skin.
- 1 March 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (6), 1852-1854
- https://doi.org/10.1073/pnas.82.6.1852
Abstract
A nonpeptide opioid was found in toad skin and purified to homogeneity by using HPLC[high performance liquid chromatography] with electrochemical detection. A nonpeptide opioid also was detected in bovine brain and adrenals as well as rabbit and rat skin, by reversed-phase HPLC following Sephadex G-15 column chromatography. The material in toad skin was identical to morphine by immunological, pharmacological and physical chemical criteria.This publication has 10 references indexed in Scilit:
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