In vitro lymphocyte stimulation by wart antigen in man

Abstract

The lymphocyte transformation test was used to study cell-mediated immunity to wart antigen in patients with active wart infections, patients with past history of warts and control subjects. A common pattern was established with wart antigen; a control baseline, followed by a rise of 14C thymidine uptake in the active group and a further elevation in the past history group. Five patients with warts were followed up and re-examined at various intervals after successful wart resolution; all except 1 responded to wart antigen by increased DNA synthetic activity after the wart resolution. This increased response was specific for wart antigen and could still be detected 6 mo. after wart resolution.