Iotroxamide—a new cholangiographic agent. Relation between plasma concentration and biliary excretion in man

Abstract

The relationship between infusion rates, plasma concentration and biliary excretion of iotroxamide were studied in 24 patients with a T-tube in situ. Plasma iotroxamide concentration was linearly related to the rate of infusion over a dose range of 0.525-6.3 mg/kg per min. Peak biliary concentrations and excretory rates of iotroxamide were seen when the plasma concentration was approximately 1500 .mu.g/ml. Using a 1 h infusion of iotroxamide near optimal concentrations of I in the bile duct apparently can be achieved with an infusion rate of around 4 mg/kg per min. No toxic effects were noticed from the use of this new cholangiographic agent.