The identification of the major diazotizable metabolite of 4:4′-diaminodiphenyl sulphone in rabbit urine
- 1 July 1956
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 63 (3), 406-408
- https://doi.org/10.1042/bj0630406
Abstract
The metabolite of 4:4''-diaminodiphenyl sulphone (DADPS) was identified as a glucuronic acid conjugate. One molecule of DADPS is combined with 1 of the acid, and ionophoresis shows that the carboxyl group of the acid is free. The metabolite is acid-labile and breaks down to glucuronic acid and DADPS. The conjugation is therefore probably between the aldehydic C and the N of 1 of the amino groups, and the linkage may be either that of an anil or an N-glucosiduronic structure. The metabolite was synthesized.Keywords
This publication has 10 references indexed in Scilit:
- Excretion products of 4:4'-diaminodiphenyl sulfone.Published by Elsevier ,1955
- The metabolites of 2-naphthylamine produced by rats and rabbits.1955
- Chemotherapy of LeprosyBMJ, 1952
- STUDIES IN SULPHONE THERAPYLeprosy Review, 1952
- Improved Spraying Reagents for the Detection of Sugars on Paper ChromatogramsNature, 1951
- THE PHARMACOLOGY OF THE SULFONESAnnals of the New York Academy of Sciences, 1949
- EVALUATION OF THE SULFONES AND STREPTOMYCIN IN EXPERIMENTAL TUBERCULOSISAnnals of the New York Academy of Sciences, 1949
- A Technique for Examining Large Numbers of Bacterial Culture Filtrates by Partition ChromatographyJournal of General Microbiology, 1949
- Studies in detoxication. 24. The metabolism of p-phenetidine (p-ethoxyaniline) with some observations on the anisidines (methoxyanilines).1949
- Studies in detoxication. 22. The metabolism of phenacetin (p-ethoxyacetanilide) in the rabbit and a further observation on acetanilide metabolism.1949