Intravenous Urography in Experimental Acute Renal Failure in the Rat

Abstract

Intravenous urography using large doses of diatrizoate has been carried out in rats suffering from acute renal failure states induced either by temporary renal ischemia or by intraperitoneal injection of mercuric chloride. All the animals were azotaemic, all had some degree of histological tubular necrosis but urine output ranged from anuria to marked polyuria. A dense nephrogram was always obtained even in animals with complete anuria. It is concluded that considerable glomerular filtration probably occurs in acute renal failure whatever the urine output.