THYROID FUNCTION ASSAY WITH RADIOIODINE. I. PHYSICAL BASIS OF STUDY OF EARLY PHASE OF IODINE METABOLISM AND IODINE UPTAKE 1

Abstract

The early metabolism of I in the human body is discussed on a mathematical basis with the object of improving the accuracy of diagnostic tests of thyroid conditions with radio-iodine. Allowance is made for changes in the I space and the effective volume of neck tissues observed by external gamma ray counting at various times after the administration of the test dose. After testing the resulting equations by experiments on a series of patients, the mean test results are combined with data deduced from the publications of other workers to give tabulated information suitable for practical use.