The Proportion of HB A2is Higher in Sickle Cell Trait Than in Normal Homozygotes
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 5 (4), 371-378
- https://doi.org/10.3109/03630268108991811
Abstract
The proportion of Hb A2 was 3.53 .+-. 0.94% in the blood of 69 persons with sickle cell trait (A/S) and 2.88 .+-. 0.69% in a like number with a normal (A/A) genotype, using a radial immunodiffusion assay. This differs significantly at the 0.1% level by the paired comparison technique. This effect evidently is due to the impaired association of .beta.S with .alpha.A chains, allowing more of the latter to combine with .delta.-chains. A similar phenomenon may account for the increased proportion of Hb A2 observed in .beta.-thalassemia. The proportion of Hb F did not differ in the 2 genotypes.This publication has 12 references indexed in Scilit:
- Competition of normal β chains and sickle haemoglobin β chains for α chains as a post-translational control mechanismNature, 1978
- Proteolytic activity in erythrocyte precursorsProceedings of the National Academy of Sciences, 1978
- Differences in Affinity of Variant β Chains for a Chains: A Possible Explanation for the Variation in the Percentages of β Chain Variants in HeterozygotesHemoglobin, 1977
- Globin synthesis in fractionated Normoblasts of beta-thalassemia heterozygotes.JCI Insight, 1975
- On the Levels of Hemoglobins F and A2 in Sickle-cell Anemia and Some Related DisordersAmerican Journal of Clinical Pathology, 1974
- Immunological quantification of hemoglobins F and A2Clinica Chimica Acta; International Journal of Clinical Chemistry, 1974
- Haemoglobin Synthesis during Erythroid Maturation in β-ThalassaemiaNature New Biology, 1972
- Qualitative and quantitative studies of sickle cell hemoglobin in homozygotes and heterozygotesClinica Chimica Acta; International Journal of Clinical Chemistry, 1968
- Rapid electrophoresis and quantitation of haemoglobins on cellulose acetateJournal of Clinical Pathology, 1965
- Studies on Abnormal HemoglobinsBlood, 1951