In vitro susceptibility of 545 isolates of Candida spp. to four antifungal agents
- 1 July 1994
- Vol. 37 (7-8), 285-289
- https://doi.org/10.1111/j.1439-0507.1994.tb00428.x
Abstract
The in vitro susceptibility to amphotericin B, fluconazole, itraconazole and ketoconazole of 545 Candida strains from patients treated at the University Hospital of the Canaries was determined by means of a microdilution test. The distribution of the species was as follows: Candida albicans (342), Candida tropicalis (70), Candida glabrata (68), Candida parapsilosis (65). Of Candida albicans isolates, 8.5% and 7.6% showed resistance to itraconazole and fluconazole respectively. Of C. tropicalis isolates 34.3%, 27.1% and 2.9% were resistant to itraconazole, fluconazole and ketaconazole respectively. For C. glabrata, 10.3% and 4.4% of the isolates under study demonstrated resistance to fluconazole and itraconazole respectively. Only 4.6% and 1.5% of C. parapsilosis isolates demonstrated resistance to fluconazole and itraconazole respectively. C. tropicalis was the most resistant strain and C. parapsilosis the most sensitive. The greatest percentages of resistance in vitro were seen with the triazoles.Keywords
This publication has 27 references indexed in Scilit:
- Antifungal agents The old and the newInfectious Diseases Newsletter, 1990
- Fluconazole and Other Azoles: Translation of in Vitro Activity to in Vivo and Clinical EfficacyClinical Infectious Diseases, 1990
- Laboratory identification and sensitivity testing of yeast isolatesActa Odontologica Scandinavica, 1990
- Susceptibility of nosocomial isolates of Candida species to LY121019 and other antifungal agentsDiagnostic Microbiology and Infectious Disease, 1989
- Comparative in vitro activity of LY121019 and amphotericin B against clinical isolates ofCandida speciesEuropean Journal of Clinical Microbiology & Infectious Diseases, 1988
- Evaluation of in vitro antifungal activity of LY121019European Journal of Clinical Microbiology & Infectious Diseases, 1988
- Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitroJournal of Antimicrobial Chemotherapy, 1986
- In-vitro studies of a new oral azole antimycotic, BAY N 7133Journal of Antimicrobial Chemotherapy, 1983
- KetoconazoleDrugs, 1982
- Speciation and amphotericin B sensitivity studies on blood isolates ofCandidafrom burned patientsJournal of Clinical Pathology, 1973