Selective Inhibition of Adrenal and Thyroid Stimulating Effect of Amphenone B by Cortisone and Thyroxine
- 1 July 1951
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 77 (3), 480-481
- https://doi.org/10.3181/00379727-77-18821
Abstract
Amphenone "B" induces a marked hypertrophy of both the thyroid and adrenal in the rat. Simultaneous admn. of thyroxin and Amphenone "B" prevents the thyroid hypertrophy without reducing the adrenal enlargement. Combined cortisone and Amphenone "B" administration prevents the adrenal enlargement without altering the thyroid hypertrophy. Thus, Amphenone "B" exerts its adrenal and thyroid effect by acting through two distinct end-points in the anterior pituitary.Keywords
This publication has 3 references indexed in Scilit:
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