The anti-anaphylactic activity of theophylline and some related xanthine derivatives
- 1 March 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 16 (3), 183-188
- https://doi.org/10.1111/j.2042-7158.1964.tb07441.x
Abstract
Theophylline and theobromine, but not caffeine and xanthine, protect sensitised guinea-pigs against anaphylactic shock induced by aerosolised antigen. There is an inhibition of release of slow reacting substance of anaphylaxis and some reduction in histamine release. The lung lipid changes associated with anaphylactic shock are prevented by pre-treatment with theophylline.Keywords
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