Experimental Attempts to Transmit Phlebotomus (Sandfly, Pappataci) and Dengue Fevers to Chimpanzees.

Abstract

Six chimpanzees inoculated with human serum believed to contain Phlebotomus(sandfly. pappataci) fever virus exhibited no clinical signs of infection. A slight febrile response in the 2 chimpanzees, whose temps, were being recorded, could not be interpreted with certainty, and no evidence, pro or con, was adduced regarding the susceptibility of chimpanzees to this virus. Nine chimpanzees inoculated with human dengue virus (Hawaii strain) also exhibited no clinical signs of infection, but evidence of inapparent infection was obtained by neutralization tests with the homologous mouse-adapted virus. None of 6 chimpanzees, whose serum was tested, had any antibodies for the dengue virus before inoculation and all developed them in high titer after inoculation.