Effects of L-Norepinephrine on Cardiac Metabolism of Dogs in Hemorrhagic Shock.

Abstract

"The myocardial metabolism in 18 intact dogs was studied during an initial control period and after the production of hemorrhagic shock. Some of the dogs were subsequently treated with l-norepinephrlne and some with blood. An abnormal myocardial metabolic pattern was demonstrated during shock which was relieved by blood infusion but not by l-norepinephrine. It is suggested that l-norepinephrine treatment does not increase the survival rate of dogs., in shock because it does not correct the basic metabolic abnormality and at the same time imposes a heavier burden of work on the heart.