An exclusion map for Von Recklinghausen neurofibromatosis.
Open Access
- 1 September 1987
- journal article
- Published by BMJ in Journal of Medical Genetics
- Vol. 24 (9), 515-520
- https://doi.org/10.1136/jmg.24.9.515
Abstract
By using all the genetic linkage data available between Von Recklinghausen neurofibromatosis (VRNF) and various loci on the autosomes, a graphical display of all the non-excluded areas is presented. The probability of VRNF being on any of the 22 autosomes is also shown. The exclusion map presented is for 90 markers that have been localised relatively accurately. Data are also presented for a further 24 markers that have not yet been adequately localised. This exclusion map shows that most of the genome has been excluded as a likely location of any locus responsible for this disorder in the majority of families. Chromosomes 5, 10, 17, and 18 remain largely unexcluded. Concentration on these parts of the genome should help in the identification of the site of the VRNF gene.Keywords
This publication has 20 references indexed in Scilit:
- Linkage studies in peripheral neurofibromatosis.Journal of Medical Genetics, 1987
- Genetic linkage studies with neurofibromatosis: the question of heterogeneity.Journal of Medical Genetics, 1987
- Linkage analysis of neurofibromatosis.Journal of Medical Genetics, 1987
- Von Recklinghausen neurofibromatosis: a linkage study of candidate and random marker genes.Journal of Medical Genetics, 1987
- Exclusion mapping.Journal of Medical Genetics, 1987
- A genomic search for linkage of neurofibromatosis to RFLPs.Journal of Medical Genetics, 1987
- Further exclusion data for the Von Recklinghausen neurofibromatosis gene: a genetic linkage study of 19 polymorphic markers.Journal of Medical Genetics, 1987
- Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.Journal of Medical Genetics, 1987
- Linkage analysis of British and Indian families with Von Recklinghausen neurofibromatosis.Journal of Medical Genetics, 1987
- Von Recklinghausen neurofibromatosis and genetic linkage studies: clinical considerations.Journal of Medical Genetics, 1987