Anemia and Granulocytopenia in Rats Fed a Diet Low in Pantothenic Acid

Abstract

Rats given certain purified diets which were low in pantothenic acid developed anemia, leucopenia, granulocytopenia and bone-marrow hypoplasia. The inclusion of pantothenic acid in these diets almost completely-prevented the appearance of these deficiency signs but therapy with this vit. was much less successful than was prophylaxis. Anemic animals appeared to respond to this treatment somewhat more consistently and rapidly than did those which were granulocytopenic. Granulocytopenic animals which were not anemic were treated successfully with Lactobacillus casei factor ("folic acid").