In Vitro Models, In Vivo Models, and Pharmacokinetics: What Can We Learn from In Vitro Models?
Open Access
- 15 September 2001
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 33 (s3), S214-S220
- https://doi.org/10.1086/321850
Abstract
In vitro pharmacokinetic models of infection can make an important contribution to the study of the pharmacodynamic properties of an antibacterial agKeywords
This publication has 27 references indexed in Scilit:
- Pharmacodynamic effects of amikacin, ciprofloxacin and imipenem on growing and non-growing Escherichia coli and Pseudomonas aeruginosaClinical Microbiology & Infection, 1999
- Pharmacodynamics of LevofloxacinJAMA, 1998
- A new time-kill method of assessing the relative efficacy of antimicrobial agents alone and in combination developed using a representative β-lactam, aminoglycoside and fluoroquinoloneJournal of Antimicrobial Chemotherapy, 1996
- In vitro pharmacodynamics of piperacillin, piperacillin-tazobactam, and ciprofloxacin alone and in combination against Staphylococcus aureus, Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 1995
- Pharmacodynamics of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with rifampin, against methicillin-susceptible and -resistant Staphylococcus aureus in an in vitro infection modelAntimicrobial Agents and Chemotherapy, 1994
- Dose ranging and fractionation of intravenous ciprofloxacin against Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of infectionAntimicrobial Agents and Chemotherapy, 1993
- Pharmacodynamics of intravenous ciprofloxacin in seriously ill patientsAntimicrobial Agents and Chemotherapy, 1993
- Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsisAntimicrobial Agents and Chemotherapy, 1993
- Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro modelAntimicrobial Agents and Chemotherapy, 1990
- Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistanceAntimicrobial Agents and Chemotherapy, 1987