Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model
Open Access
- 1 June 1990
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 34 (6), 1107-1111
- https://doi.org/10.1128/aac.34.6.1107
Abstract
An in vitro model simulating two-compartment pharmacokinetics was used to study the antibacterial activity of lomefloxacin after single oral doses of 200 and 400 mg. Lomefloxacin produced reliable bactericidal activity against gram-negative aerobic bacteria and staphylococci. Bacterial strains for which MICs were less than 0.5 microgram/ml were inhibited with both dosing schedules. Doubling the dose from 200 to 400 mg increased the bactericidal activity only against Pseudomonas aeruginosa. Against Enterococcus faecalis lomefloxacin showed no effect. Selection of resistant variants during the simulation of treatment was observed with Staphylococcus aureus and P. aeruginosa.This publication has 6 references indexed in Scilit:
- Pharmacokinetics and tissue penetration of orally administered lomefloxacinAntimicrobial Agents and Chemotherapy, 1988
- Pharmacokinetics and tolerance of lomefloxacin after sequentially increasing oral dosesAntimicrobial Agents and Chemotherapy, 1988
- In vitro activity of lomefloxacin (SC-47111; NY-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolonesAntimicrobial Agents and Chemotherapy, 1988
- Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classesAntimicrobial Agents and Chemotherapy, 1984
- Antibacterial effects of Cefroxadine, Cephalexin and Cephradine in a new in vitro pharmacokinetic model.The Journal of Antibiotics, 1982
- New In Vitro Model to Study the Effect of Antibiotic Concentration and Rate of Elimination on Antibacterial ActivityAntimicrobial Agents and Chemotherapy, 1978