QUANTITATIVE STUDIES OF PHYTOHEMAGGLUTININ-INDUCED DNA AND RNA SYNTHESIS IN NORMAL AND AGAMMAGLOBULINEMIC LEUKOCYTES
Open Access
- 1 May 1967
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 125 (5), 863-872
- https://doi.org/10.1084/jem.125.5.863
Abstract
Leukocytes from nine patients with acquired agammaglobulinemia were studied in vitro. Synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) induced by phytohemagglutinin was measured by determination of the degree of incorporation of labeled precursor. Synthesis of both DNA and RNA was decreased in the agammaglobulinemic cells. The presence of an inhibitor in the patients' sera could not be demonstrated. These results suggest that the basic defect in agammaglobulinemia is cellular rather than humoral.This publication has 33 references indexed in Scilit:
- Defective RNA Synthesis in Lymphocytes from Patients with Primary AgammaglobulinemiaScience, 1965
- SIDE-EFFECTS OF ANTIARTHRITIC DRUGSThe Lancet, 1965
- IgG (7 S Gamma Globulin) Metabolism in Hypogammaglobulinemia: Studies in Patients with Defective Gamma Globulin Synthesis, Gastrointestinal Protein Loss, or Both*JCI Insight, 1965
- FAMILIAL LYMPHOPENIA WITH AGAMMAGLOBULINÆMIA: An Attempt at Treatment by Implantation of Fœtal ThymusThe Lancet, 1965
- ACQUIRED AGAMMAGLOBULINÆMIA IN SIBLINGSThe Lancet, 1965
- SPECIFIC AND NON-SPECIFIC STIMULATION OF ANTIBODY SYNTHESIS BY HUMAN LEUCOCYTES IN VITROThe Lancet, 1965
- Failure of Lymphocytes from Hypogammaglobulinaemic Subjects to Transform in CultureBMJ, 1964
- Phytohemagglutinin Elicitation of Specific Anamnestic Immune Response in vitroScience, 1964
- Agammaglobulinemia: The Fundamental DefectScience, 1964
- The LymphocyteAnnual Review of Medicine, 1964