SEROTONIN STIMULATES INDEPENDENTLY THE ADHESION AND GROWTH OF THE MULTIPLICATION OF FIBROBLASTS IN CULTURE
- 1 January 1982
- journal article
- research article
- Vol. 24 (2), 224-226
Abstract
The influence of serotonin on the adhesion and growth processes in primary cultures of murine and human embryo fibroblasts and mouse neoplastic fibroblast L-cells was studied separately. At the moment of seeding, serotonin shortened the time of adhesion to glass surface of these from .apprx. 4 to 1 or 2 h and stimulated incorporation of [3H] thymidine and cell multiplication when introduced in 2 or 6 h cultures. Adhesion and growth stimulatory activities were blocked by serotonin antagonists, cyproheptadine and tipindole, demonstrating that the specific binding of bioamine with cell receptors is essential in both cases.This publication has 1 reference indexed in Scilit: