Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines
- 1 January 2007
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 5 (17), 2758-2761
- https://doi.org/10.1039/b709043a
Abstract
A new approach to the synthesis of 5-amino-4-cyanopyrazoles has been developed, utilising a novel flow microwave device. These products are then converted by a batch mode microwave process to structurally more complex dimeric and ‘mixed’ pyrazolopyrimidine structures.Keywords
This publication has 35 references indexed in Scilit:
- A Microcapillary Flow Disc Reactor for Organic SynthesisOrganic Process Research & Development, 2007
- Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactorOrganic & Biomolecular Chemistry, 2007
- [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactorOrganic & Biomolecular Chemistry, 2007
- Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] NanoparticlesOrganic Process Research & Development, 2007
- Synthesis of Organic Compounds Using Polymer-Supported Reagents, Catalysts, and/or Scavengers in Benchtop Flow SystemsIndustrial & Engineering Chemistry Research, 2005
- Controlled Microwave Heating in Modern Organic SynthesisAngewandte Chemie International Edition, 2004
- Continuous Flow Techniques in Organic SynthesisChemistry – A European Journal, 2003
- New tools and concepts for modern organic synthesisNature Reviews Drug Discovery, 2002
- The impact of microwave-assisted organic chemistry on drug discoveryDrug Discovery Today, 2002
- Microwave assisted organic synthesis—a reviewTetrahedron, 2001