Effects of Amphenone "UB" on Thyroid, Adrenals, and Genital Tract of the Female Rat

Abstract

Amphenone "B" (l,2-bis-(p-aminophenyl)-2-methylpropanone-l-di-HCl) administered either orally or parenterally exerts an atypical trophic action on the genital tract of the ovariectomized female rat. It also effects a rapid hypertrophy of the adrenals and thyroid. These adrenal effects are lacking in the hypophysectomized rat but the uterine stimulation is unaffected either by hypophysectomy oradrenal-ectomy. The compound also possesses an acute toxicity which is characterized by marked narcosis leading to death. The max. effective dose is approx. 2/3 of the lethal dose.