DEVELOPMENTAL-CHANGE IN STRIATAL CONCENTRATION OF HOMOVANILLIC-ACID AND 3,4-DIHYDROXYPHENYLACETIC ACID IN RESPONSE TO APOMORPHINE AND HALOPERIDOL TREATMENT
- 1 January 1979
- journal article
- research article
- Vol. 237 (1), 25-30
Abstract
The striatal concentration of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) was estimated following an injection of apomorphine into the developing rat subchronically treated with haloperidol. At the withdrawal stage of haloperidol treatment, striatal HVA and DOPAC levels decreased in rats aged 14, 24 and 34 days. The haloperidol treatment enhanced the apomorphine-induced reduction of the striatal HVA content at the withdrawal stage in the 24 day old and 34 day old rats. A functional link in the feedback control mechanism and dopamine receptors may not fully develop at birth but do so in the early stage of postnatal life.This publication has 4 references indexed in Scilit:
- Dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol of clozapineLife Sciences, 1977
- Postnatal development of dopaminergic and cholinergic catalepsy in the ratEuropean Journal of Pharmacology, 1976
- The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidolPsychopharmacology, 1976
- STUDIES ON THE NEONATAL DEVELOPMENT OF THE GLUCURONIDE CONJUGATING 12Journal of Clinical Investigation, 1958