THE INHIBITORY EFFECT OF CARONAMIDE ON THE RENAL ELIMINATION OF PENICILLIN
- 1 May 1947
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 149 (2), 355-368
- https://doi.org/10.1152/ajplegacy.1947.149.2.355
Abstract
Caronamide decreased the tubular excretion and increased the plasma concn. of penicillin G, K, F and X. Its mode of action is to halt the tubular transport mechanism for penicillin excretion. This effect was reversible and the function of the system returned to normal after admn. of the compd. was stopped. It was effective when administered orally or parenterally and when penicillin was administered by the same or a different route. The essential points in this report have been substantiated clinically.Keywords
This publication has 4 references indexed in Scilit:
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- MASSIVE DOSES OF PENICILLIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITISAnnals of Internal Medicine, 1946
- THE ABSORPTION AND EXCRETION OF PENICILLIN FOLLOWING CONTINUOUS INTRAVENOUS AND SUBCUTANEOUS ADMINISTRATIONJCI Insight, 1944
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