Chromosome Aberrations: Their Role in the Etiology of Murine Leukemia
- 9 October 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 146 (3641), 252-253
- https://doi.org/10.1126/science.146.3641.252
Abstract
If the association between chromosome aberrations and leukemia is a causal one, the aberrations should be present before the appearance of tumor. In a virus-induced murine leukemia in which the pre- and early leukemic stages were defined, aneuploidy was observed only during the later stages of the disease. This suggests that the chromosome alteration results from, rather than initiates, the neoplastic transformation.Keywords
This publication has 11 references indexed in Scilit:
- Chromosomal Aberrations in Viral Leukemogenesis. I. Friend and Rauscher Leukemia2JNCI Journal of the National Cancer Institute, 1964
- HISTOGENESIS OF THYMIC LYMPHOMA INDUCED BY MURINE LEUKEMIA VIRUS (RICH)1964
- Chromosome Studies of Virus-Induced Rabbit Papillomas and Derived Primary CarcinomasJNCI Journal of the National Cancer Institute, 1963
- Further Studies on Karyotypes of a Variety of Primary and Transplanted Mouse Polyoma Tumors2JNCI Journal of the National Cancer Institute, 1963
- SECTION OF BIOLOGICAL AND MEDICAL SCIENCES: STUDIES ON MURINE LEUKEMIA — NUCLEIC ACIDS*Transactions of the New York Academy of Sciences, 1963
- UNILATERAL HISTOGENESIS OF AKR THYMIC LYMPHOMA1963
- Chromosome patterns in primary neoplasiaExperimental Cell Research, 1963
- A Virus-Induced Disease of Mice Characterized by Erythrocytopoiesis and Lymphoid LeukemiaJNCI Journal of the National Cancer Institute, 1962
- Chromosomes in Primary Neoplastic GrowthNature, 1960
- CELL-FREE TRANSMISSION IN ADULT SWISS MICE OF A DISEASE HAVING THE CHARACTER OF A LEUKEMIAThe Journal of Experimental Medicine, 1957