A Cladistic Analysis of the Evolutionary Relationships of the Members of the Tyrosinase Gene Family Using Sequence Data
- 1 December 1994
- journal article
- research article
- Published by Wiley in Pigment Cell Research
- Vol. 7 (6), 388-393
- https://doi.org/10.1111/j.1600-0749.1994.tb00066.x
Abstract
Recently, DNA sequence data have been published on tyrosinase and tyrosinase-related proteins (TRPs) in a wide variety of vertebrates ranging from Rana to Homo. These proteins are in turn members of a larger family of binuclear copper-binding proteins, which all contain two highly conserved copper-binding domains. This gene family also includes tyrosinases from fungi and bacteria as well as arthropodan and molluscan hemocyanins. Parsimony-based alignment and tree construction algorithms (Malign, v1.85 and PAUP, 3.1.1) were used to analyze the diversification of both the evolutionarily conserved copper-binding domains in copper-binding proteins in general as well as the diversification of the vertebrate tyrosinase gene family more specifically. These analyses show that the diversification of the vertebrate tyrosinase gene family minimally predates the diversification of vertebrates. Vertebrate tyrosinases proper first diverged from an ancestral tyrosinase-related protein (TRP) that then subsequently diverged to form tyrosinase-related protein-1s (TRP-1s) and tyrosinase-related protein-2s (TRP-2s).Keywords
This publication has 24 references indexed in Scilit:
- The Identification and Partial Cloning by PCR of the Gene for Tyrosinase‐Related Protein‐1 in the Mexican AxolotlPigment Cell Research, 1995
- Molecular characterization of a human tyrosinase‐related‐protein‐2 cDNAEuropean Journal of Biochemistry, 1994
- HOM/Hox Type Homeoboxes in the Chelicerate Limulus polyphemusMolecular Phylogenetics and Evolution, 1993
- Phylogeny of Regulatory Regions of Vertebrate Tyrosinase GenesPigment Cell Research, 1992
- Panulirus interruptus hemocyanin. The elucidation of the complete amino acid sequence of subunit aEuropean Journal of Biochemistry, 1987
- Complete Amino-Acid Sequence of a Functional Unit from a Molluscan Hemocyanin(Helix pomatia)Biological Chemistry Hoppe-Seyler, 1987
- Cloning and sequencing of mouse tyrosinase cDNA.The Japanese Journal of Genetics, 1987
- The Structure of Arthropod HemocyaninsScience, 1985
- Hemocyanins in Spiders, XIX. Complete Amino-Acid Sequence of SubunitdfromEurypelma californicumHemocyanin, and Comparison to ChaineHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1983
- Hemocyanins in Spiders, XVIII. Complete Amino-Acid Sequence of SubunitefromEurypelma californicumHemocyaninHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1983