On the Effect of Thyroid Hormones on the Oxidation of 5beta-Cholestane-3alpha, 7alpha, 12alpha-triol. Bile Acids and Steroids 157.

Abstract

The oxidation of 5[beta]-cholestane-3[alpha], 7[alpha], 12[alpha]-triol was studied in homogenates of liver from hyper-, eu-, and hypothyroid rats. Liver homogenates from hyperthyroid rats, treated with 3,5,3[image]-triiodo-L-thyronine for one week, showed an increase in capacity to oxidize this substrate as compared with normal rats, whereas liver homogenates from hypothyroid rats showed a decrease. After 3 weeks of treatment with thyroid hormone, the difference between hyperthyroid and normal rats with respect to oxidation of 5[beta]-cholestane-3[alpha],7[alpha], 12[alpha]-triol was increased. Addition of NADPH [nicotinamide adenine dinucleotide phosphate] stimulated the oxidation to the same extent in both groups of homogenates.