Peptide synthesis. Part 9. Solid-phase synthesis of melanin concentrating hormone using a continuous-flow polyamide method
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 361-367
- https://doi.org/10.1039/p19860000361
Abstract
Synthesis of the heptadecapeptide melanin concentrating hormone using a novel continuous-flow solid-phase method is described. A composite polydimethylacrylamide–macroporous kieselguhr support was used permitting low pressure flow operation. Fluorenylmethoxycarbonylamino acid anhydrides were used throughout for acylation reactions. The choice of compatible side-chain protecting groups is discussed. The synthetic product showed high melanin-concentrating properties in vitro.This publication has 10 references indexed in Scilit:
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