Sequential Coagulation Studies in Purpura Fulminans

Abstract

CORRECTION of abnormally low concentration of plasma components is usually attempted by replacement therapy. However, evidence from studies of purpura fulminans in man^{1 , 2} and from studies of the Shwartzman reaction in rabbits^{3 , 4} suggests that the coagulation deficiencies associated with these pathologically similar conditions⁵ are corrected more by anticoagulant therapy than by replacement therapy. This seemingly paradoxical treatment has developed with the concept that the deficiencies observed are due to intravascular coagulation.⁶ Indeed, these deficiencies are simitar to those existing in serum after in vitro coagulation of blood – for example, deficiencies of platelets and factors I (fibrinogen), II (prothrombin), V . . .